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  1. Kim, K.H., Noh, K., Lee, J. & Lee, Sujin, Lee, S. J. Neuronal growth regulator 1 modulates mouse affective discrimination by regulating adult olfactory neurogenesis. Biological Psychiatry: Global Open Science (2024)


  1. Lee, J., Chung, S., Hwang, M., Kwon, Y., Han, S. H., & Lee, S. J. Estrogen Mediates the Sexual Dimorphism of GT1b-Induced Central Pain Sensitization. Cells, 12(5), 808 (2023)

  2. Lee, J., Lee, G., Ko, G., & Lee, S. J. Nerve injury-induced gut dysbiosis contributes to spinal cord TNF-α expression and nociceptive sensitization. Brain, Behavior, and Immunity (2023)

  3. Barcelon E, Chung S, Lee J, Lee SJ. Sexual Dimorphism in the Mechanism of Pain Central Sensitization. Cells (2023)

  4. Noh, K., Cho, WH., Lee, B.H., Kim, DW., Kim, YS., Park, KB., Hwang, MK., Barcelon E., ..., & Lee, S. J. Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance. Nat Neurosci (2023).


  1. Yoo A, Joo Y, Cheon Y, Lee SJ, Lee S. Neuronal growth regulator 1 promotes adipocyte lipid trafficking via interaction with CD36. J Lipid Res. 63(6):100221 (2022)

  2. Oh J, Cho W, Barcelon E, Kim KH, Hong J, Lee SJSARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death. Sci Rep. 12(1):5496 (2022)

  3. Cho WH, Noh K, Lee BH, Barcelon EE, Jun SB, Park HY, and Lee SJHippocampal astrocytes modulate anxiety-like behavior. Nat Commun 13, 6536 (2022)


  1. Lee J, Hwang H, Lee SJDistinct roles of GT1b and CSF-1 in microglia activation in nerve injury-induced neuropathic pain. Mol Pain. 17:17448069211020918(2021)

  2. Song B, Lee S, Kim C. Roles of Cytokines in the Temporal Changes of Microglial Membrane Currents and Neuronal Excitability and Synaptic Efficacy in ATP-Induced Cortical Injury Model. Int J Mol Sci. 22(13):6853(2021)

  3. Choi B, Ahn M, Hong S, Barcelon EE, Sangshetti J, Arote RB, Lee SJ. Development of novel, biocompatible, polyester amines for microglia-targeting gene delivery. RSC Adv. 11:36792-36800(2021)


  1. Won S, Park K, Lim H, Lee SJ. Sexual dimorphism in cognitive disorders in a murine model of neuropathic pain. Behav Brain Funct. 16:1(2020).

  2. Lim H, Lee J, You B, Oh JH, Mok HJ, Kim YS, Yoon BE, Kim BG, Back SK, Park JS, Kim KP, Schnaar RL, Lee SJ. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain. EMBO J. 39:e102214 (2020).

  3. Noh K, Park JC, Han JS, Lee SJ. From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders. Exp Neurobiol. 29(1):1-10(2020).

  4. Park K, Lee SJ.  Deciphering the star codings: astrocyte manipulation alters mouse behavior. Exp Mol Med. 52(7):1028-1038(2020).

  5. Jo YR, Kim HR, Jang SY, Go H, Song M, Park DK, Oh Y, Jo J, Shin YK, Lee SJ, Cheon S, Lee HK, Lee KE, Kim YH Park HT. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB J. 35(1):e21225(2020).


  1. Noh K, Lee H, Choi TY, Joo Y, Kim SJ, Kim H, Kim JY, Jahng JW, Lee S, Choi SY, Lee SJ. Negr1 controls adult hippocampal neurogenesis and affective behaviors. Mol Psychiatry, 24:1189-1205(2019). This article is selected as 'Featured Image' in the Molecular Psychiatry. Title: "Negr1 regulates hippocampal Lcn2 expression and affective behaviour via interaction with LIF receptor" (Mol. Psychiatry 24:1095(2019))

  2. Barcelon EE, Cho WH, Jun SB, Lee SJ. Brain Microglial Activation in Chronic Pain-Associated Affective Disorder. Front Neurosci. 15;13:213(2019).

  3. Choi B , Soh M , Manandhar Y , Kim D , Han SI , Baik S , Shin K , Koo S , Kwon HJ , Ko G , Oh J , Hwang H , Hyeon T , Lee SJ. Highly selective microglial uptake of ceria-zirconia nanoparticles for enhanced analgesic treatment of neuropathic pain. Nanoscale. 11:19437 (2019).

  4. Lee JW, Nam H, Kim LE, Jeon Y, Min H, Ha S, Lee Y, Kim SY, Lee SJ, Kim EK, Yu SW. TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia. Autophagy. 15(5):753-770 (2019).

  5. Jang M, Choi JH, Chang Y, Lee SJ, Nah SY, Cho IH. Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: Activation of the Nrf2 pathway through lysophosphatidic acid receptors. Brain Behav Immun. 80;146-162 (2019).


  1. Nho B, Lee J, Lee J, Ko KR, Lee SJ, Kim S. Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. FASEB J. 32(9):5119-5131 (2018).

  2. Kim D, Yoo JM, Hwang H, Lee J, Lee SH, Yun SP, Park MJ, Lee M, Choi S, Kwon SH, Lee S, Kwon SH, Kim S, Park YJ, Kinoshita M, Lee YH, Shin S, Paik SR, Lee SJ, Lee S, Hong BH, Ko HS. Graphene quantum dots prevent α-synucleinopathy in Parkinson'sdisease. Nat Nanotechnol. 13:812-818 (2018).

  3. Min H, Cho WH, Lee H, Choi B, Kim YJ, Lee HK, Joo Y, Jung SJ, Choi SY, Lee S & Lee SJ. (2018). Association of TRPV1 and TLR4 through the TIR domain potentiates TRPV1 activity by blocking activation-induced desensitization. Molecular pain, 14:1-10 (2018).


  1. Kim HChoi BLim HMin HOh JHChoi SCho JGPark JSLee SJPolyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodyniaMol Pain. 13:1-11 (2017).

  2. Shin WGPark BJLee SJKim JGInfection of human intestinal epithelial cells by invasive bacteria activates NF-κB and increases ICAM-1 expression through NOD1Korean J Intern Med. 33(1):81-90 (2018).

  3. Kim H, Chun Y, Che L, Kim J, Lee SJ, Lee S. The new obesity-associated protein, neuronal growth regulator 1 (NEGR1), is implicated in Niemann-Pick disease Type C (NPC2)-mediated cholesterol trafficking. Biochem Biophys Res Commun. 482(4):1367-1374 (2017).

  4. Min H, Choi B, Jang YH, Cho IH, Lee SJ. Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage. Mol Brain. 10(1):27 (2017).

  5. Lim H, Lee H, Noh K, Lee SJ. IKK/NF-κB-dependent satellite glia activation induces spinal cord microglia activation and neuropathic pain after nerve injury. Pain. 158(9):1666-1677 (2017).

  6. Kim EJ, Jang M, Lee MJ, Choi JH, Lee SJ, Kim SK, Jang DS, Cho IH. Schisandra chinensis Stem Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity via Activation of the Nrf2 Pathway and Inhibition of the MAPKs and NF-κB Pathways. Front Pharmacol. 8:673 (2017).


  1. Cho WHBarcelon ELee SJOptogenetic Glia Manipulation: Possibilities and Future ProspectsExp Neurobiol. 25(5):197-204 (2016).

  2. Lee HBaek JMin HCho IHYu SWLee SJToll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve InjuryNeuroimmunomodulation. 23(4):209-216 (2016).

  3. Yi MHZhang EKim JJBaek HShin NKim SKim SRKim HRLee SJPark JBKim YKwon OYLee YHOh SHKim DW, CD200R/Foxp3-mediated signalling regulates microglial activationSci Rep. 6(1):34901 (2016).

  4. Lee MJBing SJChoi JJang MLee GLee HChang BSJee YLee SJ, ChoIH, IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrierMol Neurodegener. 11(1):54 (2016).

  5. Min H, Jang YH, Cho IH, Yu SW, Lee SJAlternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage, Mol Brain. 9(1):42 (2016).



  1. Shin WH, Joen MT,  Leem E, Won SY, Jeong KH, Park S-J, McLean C, Lee SJ, Jin BK, Jung UJ, Kim SR, Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease, Sientific Report, 5:14764 (2015).

  2. Yoon H, Jang YH, Kim SJ, Lee SJ, Kim SK. (co-correspondence) Toll-like Receptor 2 is Dispensable for an Immediate-early    Microglial Reaction to Two-photon Laser-induced Cortical Injury In vivo. Korean J Physiol Pharmacol. 19(5):461-5 (2015).

  3. Lee SJ. Molecular mechanisms of itch and pain: An overview. Itch & Pain, 2015, 2 (1). (DOI: 

  4. Lee MJ, Jang M, Choi J, Lee G, Min HJ, Chung WS, Kim JI, Jee Y, Chae Y, Kim SH, Lee SJ, Cho IH. Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses. Mol Neurobiol. 53(3):1499-1445 (2016).

  5. Min H, Hong J, Cho I-H, Jang YH, Lee H, Kim D, Yu S-W, Lee S, Lee SJ, TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates intracerebral hemorrhage animal models. Mol. Brain 8:23 (2015).



  1. Choi JY, Cui Y, Kang YM, Kim JH, Lee SJ, Kim BG. Role of toll-like receptor 2 in ischemic demyelination and oligodendrocyte death. Neurobiol Aging. 35:1643-1653 (2014).

  2. Hayward JH, Lee SJ. A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases. Exp Neurobiol. 23(2):138-47 (2014).

  3. Hwang H, Min H, Kim D, Yu SW, Jung SJ, Choi SY, Lee SJ. Imiquimod induces a Toll-like receptor 7-independent increase in intracellular calcium via IP3 receptor activation. Biochem Biophys Res Commun. 450(1):875-9 (2014).

  4. Lee K, Kim SJ, Kim D, Jo SH, Lee SJ, Choi SY. Prostaglandin modulates TLR3-induced cytokine expression in human astroglioma cells. Brain Res. 2014 Jul 8

  5. Min H, Lee H, Lim H, Jang YH, Chung SJ, Lee CJ, Lee SJTLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity. Mol Brain. 21;7(1):59 (2014).



  1. Lee HM, Kang J, Lee SJ, Jo EK. Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria. Glia. 61(3):441-52 (2013).

  2. Lim HS, Kim D, Lee SJ. Toll-like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia. J. Biol. Chem. 288(11):7572-9 (2013).

  3. Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, Lee SJ, Masliah E, Hwang D, Lee HJ, Lee SJ. Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun. 4:1562 (2013).

  4. Lee H, Lee S, Cho IH, Lee SJ. Toll-like receptors: sensor molecules for detecting damage to the nervous system. Curr Protein Pept Sci. 14(1):33-42 (2013).

  5. Yang CS, Kim JJ, Lee SJ, Hwang JH, Lee CH, Lee MS, Jo EK. TLR3-Triggered Reactive Oxygen Species Contribute to Inflammatory Responses by Activating Signal Transducer and Activator of Transcription-1. J Immunol. 190(12):6368-77 (2013).

  6. Suh EC, Jung YJ, Kim YA, Park EM, Lee SJ, Lee KE. Knockout of Toll-like receptor 2 attenuates Aβ25-35-induced neurotoxicity in organotypic hippocampal slice cultures. Neurochem Int. 63(8):818-25 (2013).



  1. Lee J, Kim T, Hong J, Woo J, Min H, Hwang E, Lee SJ (co-correspondence), Lee CJ. Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K2P) and voltage-gated (Kv1.1 and Kv1.2) potassium channels. Mol. Pain. 8(1):2 (2012).

  2. Lee HK, Park DW, Bae JH, Kim HJ, Shin DG, Park JS, Lee JG, Lee SJ, Bae YS, Baek SH. RGS2 is a negative regulator of STAT3-mediated Nox1 expression. Cell Signal. 24(3):803-9 (2012).

  3. Jung BK, Pyo KH, Shin KY, Hwang YS, Lim H, Lee SJ, Moon JH, Lee SH, Suh YH, Chai JY, Shin EH. Toxoplasma gondii infection in the brain inhibits neuronal degeneration and learning and memory impairments in a murine model of Alzheimer's disease. PLoS One. 7(3):e33312 (2012).

  4. Hong J, Kim BK, Lim H, Lee S, Lee SJ. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol. 34(6): 912-918 (2012).

  5. Seo J, Hong J, Lee SJ, Choi SY  c-Jun N-terminal phosphorylation is essential for hippocampal synaptic plasticity. Neurosci Lett. 531(1):14-9 (2012).



  1. Oh GS, Kim HJ, Choi JH, Shen A, Kim CH, Kim SJ, Shin SR, Hong SH, Kim Y, Park C, Lee SJ, Akira S, Park R, So HS. Activation of lipopolysaccharide-TLR4 signaling accelerates the ototoxic potential of cisplatin in mice. J Immunol. 186(2):1140-50 (2011).

  2. Kim SJ, Park GH, Kim D, Lee J, Min H, Wall E, Lee CJ, Simon MI, Lee SJ (co-correspondence), Han S-K. Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in TRPV1-expressing neurons. PNAS, 108(8):3371-6 (2011).

  3. Kyung Jin Jung, Dong Woon Kim, Ha Na Lee, Mi Ok Lee, Sung Joong Lee, Jeong-Hwan Che, Yong Ho Lee, Byeong-Cheol Kang. The role of Endothelin receptor A during myelination ofdeveloping oligodendrocytes, Journal of Korean Medical Science, 26(1):92–99 (2011).

  4. Kang J, Jiang MH, Lee H, Jo EK, Karin M, Yune TY,  Lee SJ. IKK beta-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur. J. Immunol.  41:1266-1277 (2011).

  5. Kim D, You B, Lim H, and Lee SJ. Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury. Mol. Pain, 7:74-83 (2011).



  1. Park C, Lee S, Park K, Kim JS, Lee SJ. Synergy of TLR2 and H1R on Cox-2 expression in pulp cells. J. Dent. Res. 2010, 89(2): 180-185.

  2. Kang SS, Han KS, Ku BM, Lee YK, Hong J, Shin HY, Almonte AG, Woo DH, Brat DJ, Hwang EM, Yoo SH, Chung CK, Park SH, Paek SH, Roh EJ, Lee SJ, Park JY, Traynelis SF, Lee CJ.  Caffeine-Mediated Inhibition of Calcium Release Channel Inositol 1,4,5-Trisphosphate Receptor Subtype 3 Blocks Glioblastoma Invasion and Extends Survival. Cancer Res. 2010, 70(3), 1173-83.

  3. Kim D, Cho SH, Kim JS, Jo SH, Lee SJ, Kim KT, Choi SY. Human astrocytic bradykinin B(2) receptor modulates zymosan-induced cytokine expression in 1321N1 cells. Peptides. 2010 Jan;31(1):101-7.

  4. Park JS, Yoo SB, Kim JY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K, Jahng JW, Choi SY. Effects of saccharin intake on  hippocampal and cortical plasticity in juvenile and adolescent rats. Korean J Physiol Pharmacol. 2010 Apr;14(2):113-8.

  5. Li J, Jeong MY, Bae JH, Shin YH, Jin M, Hang SM, Lee JC, Lee SJ, Park K. Toll-like receptor 3-mediated induction of chemokines in salivary epithelial cells. Korean J Physiol Pharmacol. 2010 Aug; 14: 235-240.

  6. Kim D, Yoo B, Jo E-K, Han S-K, Simon MI, Lee SJ. Nox2-derived ROS in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. PNAS. 2010, 107 (33): 14851-14856.

  7. Hong J, CHO IH, Suh EC, Kwak KI, Seo JS, Choi SY Park HW, Jo EK, Lee S, Lee K, Lee SJ. Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J Biol Chem. 2010 Dec 10;285(50):39447- 57.



  1. Lee H, Park K, Kim JS, Lee SJ. Vasoactive intestinal peptide inhibits TLR3-induced nitric oxide production in Schwann cells and subsequent sensory neuronal death. J. Neurosci. Res. 2009. 87: 171-178.

  2. Kim D, Lee S, Lee SJ. Toll-like receptors in peripheral nerve injury and neuropathic pain. Current Topics in Microbiology and Immunology. 2009. 336:169-186.

  3. Yang CS, Yuk JM, Shin DM, Kang J, Lee SJ, Jo EK. Secretory phospholipase A2 plays an essential role in microglial inflammatory responses to Mycobacterium tuberculosis. Glia. 2009 Aug 1;57(10):1091-103.

  4. Kim JH, Park SH, Moon YW, Hwang S, Kim D, Jo SH, Oh SB, Kim JS, Jahng JW, Lee  JH, Lee SJ, Choi SY, Park K. Histamine H1 receptor induces cytosolic calcium increase and aquaporin translocation in human salivary gland cells. J Pharmacol Exp Ther. 2009 Aug;330(2):403-12.

  5. Hwang SM, Li J, Koo NY, Choi SY, Lee SJ, Oh SB, Castro R, Kim JS, Park K. Role of purinergic receptor in alpha fodrin degradation in Par C5 cells. J Dent Res. 2009 Oct;88(10):927-32.




  1. Park C, Cho I-H, Kim D, Jo E-K, Choi S-Y, Oh SB, Park K, Kim JS, Lee SJ. Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury. Neuroscience Lett. 2008 Jan 31;431(2):123-8.

  2. Yang CS, Shin DM, Lee HM, Son JW, Lee SJ, Akira S, Gougerot-Pocidalo MA, El-Benna J, Ichijo H, Jo EK. ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signaling. Cell Microbiol. 2008 Mar;10(3):741-54.

  3. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, Kim JS, Lee EB, Song YW, Park K. Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjogren's syndrome patients. Rheumatology (Oxford). 2008 Jun;47(6):828-33.

  4. Shin DM, Yang CS, Yuk JM, Lee JY, Kim KH, Shin SJ, Takahara K, Lee SJ, Jo EK. Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1. Cell Microbiol. 2008 Aug; 10(8): 1608-1621.

  5. Shin DM, Yang CS, Lee JY, Lee SJ, Choi HH, Lee HM, Yuk JM, Harding CV, Jo EK. Mycobacterium tuberculosis lipoprotein- induced association of TLR2 with protein kinase C xi in lipid rafts contributes to reactive oxygen species-dependent inflammatory signaling in macrophages. Cell Microbiol. 2008 Sep. 10(9):1893-1905.

  6. Cho I-H, Hong J, Suh EC, Lee H, Lee S, Jo E-K, Lee K, Karin M and Lee SJ, Role of microglial IKK in kainic acid-induced hippocampal neuronal cell death. Brain. 2008. Nov. 131:3019-3033.



  1. 1. Yang CS, Lee JS, Song CH, Hur GM, Lee SJ, Tanaka S, Akira S, Paik TH, Jo EK. Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2. Cell Microbiol. 2007, Feb. 9,  9(2) : 382-396.

  2. Lee H, Park C, Cho IH, Kim HY, Jo EK, Lee S, Kho HS, Choi SY, Oh SB, Park K, Kim JS, Lee SJ. Double-stranded RNA Induces iNOS Gene Expression in Schwann Cells, Sensory Neuronal Death, and Peripheral Nerve Demyelination. Glia. 2007, 55:712-722.

  3. Kim D, Kim MA, Cho IH, Kim MS, Lee S, Jo EK, Choi SY, Park K, Kim JS, Akira S, Na HS, Oh SB, Lee SJ. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem. 2007, May 18;282(20):14975-14983.

  4. Yoshida H, Imaizumi T, Lee SJ, Tanji K, Sakaki H, Matsumiya T, Ishikawa A, Taima K, Yuzawa E, Mori F, Wakabayashi K, Kimura H, Satoh K. Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA. Neurosci. Res. 2007, 58:199-206.

  5. Ko HG, Lee SJ, Son H, Kaang BK. Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro. Mol. Pain 2007 Jun 15;3(1):16.

  6. Li HY, Park CK, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. Eugenol inhibits K+ currents in trigeminal ganglion neurons. J Dent Res. 2007 Sep;86(9):898-902.

  7. Yang CS, Lee HM, Lee JY, Kim JA, Lee SJ, Shin DM, Lee YH, Lee DS, El-Benna J, Jo EK. Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia. J. Neuroinflammation. 2007 Nov 26;4:27.



  1. Park C, S Lee, I Cho, H Lee, D Kim, S-Y Choi, S B Oh, K Park, J S Kim, and Sung Joong Lee, 2006. A TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. GLIA. 53:248-256. (Feb.1)

  2. Kim MS, Park CK, Yeon KY, Li HY, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. 2006. Involvement of transient receptor potential vanilloid-1 in calcium current inhibition by capsaicin. Neuroreport. 17(2):145-149. (Feb. 6)

  3. Cho IH, Chung YM, Park CK, Park SH, Li HY, Kim D, Piao ZG, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. 2006 Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat. Brain Res. 1072(1): 208-214. (Feb 9)

  4. Piao ZG, Cho IH, Park CK, Hong JP, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB. 2006. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain. 121(3):219-31. (Apr. 1)

  5. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, Kim JS, Lee JH, Park K. 2006. Molecular cloning and functional expression of a sodium bicarbonate cotransporter from guinea-pig parotid glands. Biochem. Biophys. Res. Commun. 342(4):1114-22. (Apr. 21).

  6. Piao L, Ying Li H, Park CK, Cho IH, Piao ZG, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. Mechanosensitivity of voltage- gated K(+) currents in rat trigeminal ganglion neurons. J. Neurosci. Res. 2006 May 15;83(7):1373-80.)

  7. Park CK, Kim MS, Fang Z, Li HY, Jung SJ, Choi SY, Lee SJ, Park K, Kim JS, Oh SB. Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain. J Biol Chem. 2006 Jun 23;281(25):17304-11.

  8. Li J, Koo NY, Cho IH, Kwon TH, Choi SY, Lee SJ, Oh SB, Kim JS, Park K. Expression of sodium bicarbonate cotransporter and its role in pHi regulation in guinea pig salivary glands. Am J Physiol Gastrointest Liver Physiol. 2006 Dec;291(6):G1031-40.

  9. Lee H, Choi S-Y, Oh SB, Park K, Kim JS, Lee SJ. Damaged neuronal cells induce inflammatory gene expression in Schwann cells. Int. J. Oral Biol., 31(3):87-92. (Sep. 30.)

  10. Choi SY, Li J, Jo SH, Lee SJ, Oh SB, Kim JS, Lee JH, Park K. Desipramine inhibits na+/h+ exchanger in human submandibular cells. J Dent Res. 2006 Sep;85(9):839-43.

  11. Li J, Lee S, Choi SY, Lee SJ, Oh SB, Lee JH, Chung SC, Kim JS, Lee JH, Park K. Effects of pilocarpine on the secretory acinar cells in human submandibular glands. Life Sci. 2006 Nov 25;79(26):2441-7.

  12. Park CK, Li HY, Yeon KY, Jung SJ, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB. Eugenol inhibits sodium currents in dental afferent neurons. J Dent Res. 2006 Oct;85(10):900-4.

  13. Lee H, Jo EK, Choi SY, Oh SB, Park K, Soo Kim J, Lee SJ. Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: Implication in Wallerian degeneration. Biochem Biophys Res Commun. 2006 Nov 24;350(3):742-7.



  1. Kyu-Young Yeon, Mi-Young Sim, Se-Young Choi, Sung Joong Lee, Kyungpyo Park, Joong Soo Kim, Jong-Heun Lee, Kyung- Mi Lee and Seog Bae Oh. 2004. Molecular Mechanisms Underlying Calcium Current Modulation By Nociceptin. Neuroreport. 15(14):2205-9. (Oct. 5)

  2. Hyo-Chel Ryu, Zheng Gen Piao, Se-Young Choi, Sung Joong Lee, Kyungpyo Park, Joong Soo Kim, and Seog Bae Oh, 2005.     GABAergic Synaptic Input to Mesencephalic Trigeminal Neurons in Rat. Int. J. Oral Biol., 30(2):71-76. (Jun. 30.)

  3. Lee, MH, Yeon, K-Y, Park, C-K, Li, H-Y, Fang Z, Kim, MS, Choi, S-Y, Lee, S. J., Lee, S, Park K, Lee, J-H, Kim JS, S.B. Oh. 2005. Eugenol inhibits calcium currents in dental afferent neurons. J. Dent. Res. 84(9):848-851. (Sep. 1)

  4. Park, DJ, Park, SA, Yoon, TG, Lee, S. J., Yum, KW, HJ Kim. 2005. Bupivacaine induces apoptosis via ROS in the Schwann cell line.  J. Dent. Res. 84(9):852-857. (Sep. 1)




  1. Kim, J.G., Lee S. J., and Kagnoff M.F. 2004. Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infection & Immunity, 72(3):  1487-1495. (Mar. 1)

  2. Lee, S., Hong, J., Choi, S., Oh, S. B., Park, K., Kim, J. S., Karin, M., S. J. Lee. 2004. CpG oligonucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kB activation. J. Neuroimmunol. 153:50-63. (Aug. 1)

  3. Lee, M.H., Yeon, K-Y., Fang, Z., Kim, M.S., Park, C-K., Choi, S-Y., Lee, S. J., Park, K., Lee, J-H., Oh, S.B., J.S. Kim. 2004. Differential effects of transient receptor potential vanilloid ligands on calcium currents. Int. J. Oral Biol., 29(3):93-98. (Sept. 30.)

  4. Lee, H., Park, C., Choi, S., Oh, S. B., Park, K., Kim, J., S. J. Lee. 2004. Double-stranded RNA induces inflammatory gene expression in Schwann cells: Implication in the Wallerian degeneration. Korean J. Physiol. Pharmacol. 8:253-257. (Oct. 1)

  5. Li, J., Ha, Y-M., Ku, N-Y, Choi, S-Y, Lee, S. J., Oh, S.B. Kim, J-S, Lee, J-H, Lee, E.B., Song, Y.W., Park, K., 2004. Inhibitory effects of autoantibodies on the muscarinic receptors in Sjogren's syndrome.  Lab. Invest. 84:1430-1438. (Nov. 1)

  6. Bang, G-Y., Pioa, Z.G., Choi, S-Y., Lee, S. J., Park, K., Kim, J.S., S.B. Oh. 2004. Changes in expression of high-voltage- activated calcium channel in facial motoneurons following facial nerve injury. Int. J. Oral Biol., 29(4):127-132. (Dec. 31.)



  1. Sim, M-Y., Yeon, K-Y., Choi, S-Y., Lee, S.J., Park, K., Lee, J., Oh, S.B., Kim. J-S. 2003. Modulation of calcium currents by nociceptin/orphanin FQ in trigeminal neurons. Int. J. Oral Biol., 28(2): 43-47. (Aug. 1.)



  1. Lee, S. J. and S. Lee. 2002. Toll-like receptors and inflammation in the CNS. Current Drug Targets-Inflammation & Allergy.  1:181-191.



  1. Choi, C., Xu, X., Oh, J. W., Lee, S. J., Gillespie, G. Y., Park, H., Jo, H., and E. N. Benveniste. 2001. Fas- induced expression of chemokines in human glioma cells: Involvement of ERK1/ERK2 and p38 MAP kinases. Cancer Res. 61 (7): 3084-3091.

  2. Lee, S. J., Drabik, K., E. N. Benveniste. 2001. Cloning of rat calcium-modulating cyclophilin ligand. DNA Seq. 12 (3): 209-213.



  1. Lee, S. J., Zhou, T., Choi C., Wang, Z., and E. N. Benveniste. 2000. Differential regulation and function of Fas expression on glial cells. J. Immunol. 164:1277-1285.

  2. Lee, S. J., Drabik, K., Van Wagoner, N. J., Lee, S., Choi, C., Dong, Y., and E. N. Benveniste. 2000. ICAM-1-induced expression of proinflammatory cytokines and chemokines in astrocytes: Involvement of ERK and p38 MAP kinases.  J. Immunol. 165:4658-4666.




  1. Lee, S. J., Park, J. Y., Hou, J., and E. N. Benveniste. 1999. Transcriptional regulation of the intercellular adhesion molecule-gene by proinflammatory cytokines in human astrocytes. GLIA. 25: 21-32.

  2. Lee, S. J., and E. N. Benveniste. 1999. Adhesion molecule expression and regulation on cells of the central nervous system. J. Neuroimmunol. 98:77-88.



  1. Lee, S. J., Hou, J., and E. N. Benveniste. 1998. Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF-kB and C/EBP isoforms. J. Neuroimmunol. 92: 196-207.



  1. Agrawal, A., Lee, S. J., Carson, M., Narayana, S. V. L., Greenhough, T. J., and J. E. Volanakis. 1997. Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein. J. Immunol. 158: 345-350.

  2. Goldsmith, J. F., Lee, S. J., Jiang, J., and S. J. Frank. 1997. Growth hormone induces detergent insolubility of GH receptors in IM-9 cells. Am. J. Physiol. 273: E932-E941.



  1. Kwon, J., Lee, S. J., and E. N. Benveniste. 1996. A 3’ cis-acting element is involved in TNF-a gene expression in astrocytes. J. Biol. Chem. 271: 22383-22390.

  2. Shrikant, P., Lee, S. J., Kalvakolanu, I., Ransohoff, R. M., and E. N. Benveniste. 1996. Stimulus-specific inhibition of intercellular adhesion molecule-1 gene expression by TGF-b. J. Immunol. 157: 892-900.


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